Vascular endothelium plays a key role in the local regulation of vascular tone and vascular
architecture by release of vasodilator and vasoconstrictor substances, as well as factors with …

Nitric oxide (NO), an enzymatic product of nitric oxide synthase (NOS), has been associated
with a variety of neurological diseases such as Alzheimer's disease (AD). NO has long been …

Background & Aims: Previous studies have suggested that a specific class of interstitial cells
of Cajal (ICC) act as mediators in nitrergic inhibitory neurotransmission. The aim of this …

Autism spectrum disorders (ASDs) include a wide range of neurodevelopmental disorders.
Several reports showed that mutations in different high‐risk ASD genes lead to ASD …

Nitrergic enteric neurons are key players of the descending inhibitory reflex of intestinal
peristalsis, therefore loss or damage of these neurons can contribute to developing …

Despite increasing understanding of the pathophysiology of achalasia, the etiology of this
esophageal motility disorder remains largely unknown. However, the occurrence of familial …

Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional
gastrointestinal (GI) disorder, which occurs more frequently in women than men. The aim of …

Nitric oxide (NO) is an important inhibitoryneurotransmitter in the gut. Alterations in NO
mediatedresponses have been described in diabetic animals. Thepresence of nitric oxide …

The authors review ten essential amino acids with regard to their metabolic, physiologic and
therapeutic effects throughout the human body. Physical properties of these biologically …

It is commonly accepted that females and males differ in their experience of pain. Gender
differences have been found in the prevalence and severity of pain in both clinical and …