There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

Multisystem inflammatory syndrome in children (MIS-C) occurs during or recently following
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and is …

The intestinal surface is constitutively exposed to diverse antigens, such as food antigens,
food-borne pathogens, and commensal microbes. Intestinal epithelial cells have developed …

Improved hygiene leading to reduced exposure to microorganisms has been implicated as
one possible cause for the recent “epidemic” of chronic inflammatory diseases (CIDs) in …

Background Celiac disease remains a challenging condition because of a steady increase
in knowledge tackling its pathophysiology, diagnosis, management, and possible …

An increased intestinal permeability has been described in various gastrointestinal and non-
gastrointestinal disorders. Nevertheless, the concept and definition of intestinal permeability …

Celiac disease is an immune-mediated systemic disease triggered by intake of gluten in
genetically susceptible individuals. The prevalence of celiac disease in the general …

Mixed lineage kinase domain-like (MLKL) is the terminal protein in the pro-inflammatory
necroptotic cell death program. RIPK3-mediated phosphorylation is thought to initiate MLKL …

Coeliac disease is an immune-mediated enteropathy against dietary gluten present in
wheat, rye and barley and is one of the most common lifelong food-related disorders …