Itch pathogenesis is broadly characterized into histaminergic and nonhistaminergic
pathways and transmitted via 2 main receptor families: G protein–coupled receptors and …

Pruritus is a common symptom of several skin diseases, both inflammatory and neoplastic.
Pruritus might have a tremendous impact on patients' quality of life and strongly interfere …

Nociceptive pain is a hallmark of many chronic inflammatory conditions including
inflammatory bowel diseases (IBDs); however, whether pain-sensing neurons influence …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

The epidermis is a barrier that prevents water loss while keeping harmful substances from
penetrating the host. The impermeable cornified layer of the stratum corneum is maintained …

Atopic dermatitis (AD) is among the most frequent inflammatory skin diseases in humans,
affecting up to 20% of children and 10% of adults in higher income countries. Chronic …

In dermatological research, 2, 4-dinitrochlorbenzene (DNCB)-induced atopic dermatitis (AD)
is a standard model as it displays many disease-associated characteristics of human AD …

Skin appearance is essential for self‐esteem and quality of life; consequently, skin care
products represent a huge market. In particular, cosmeceuticals constitute a hybrid category …

Type 2 immune–mediated diseases give a clear answer to the issue of nature (genetics)
versus nurture (environment). Both genetics and environment play vital complementary roles …

Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching.
The pathophysiology of AD is multifactorial, involving environmental factors, genetic …