Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Pathophysiological mechanisms in migraine and the identification of new therapeutic targets
KA Haanes, L Edvinsson - CNS drugs, 2019 - Springer
Migraine is a strongly disabling disease characterized by a unilateral throbbing headache
lasting for up to 72 h for each individual attack. There have been many theories on the …
lasting for up to 72 h for each individual attack. There have been many theories on the …
Discrete subicular circuits control generalization of hippocampal seizures
F Fei, X Wang, C Xu, J Shi, Y Gong, H Cheng… - Nature …, 2022 - nature.com
Epilepsy is considered a circuit-level dysfunction associated with imbalanced excitation-
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …
inhibition, it is therapeutically necessary to identify key brain regions and related circuits in …
Hyperpolarization-activated cyclic nucleotide-gated channels as drug targets for neurological disorders
B Santoro, MM Shah - Annual review of pharmacology and …, 2020 - annualreviews.org
The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
ion channels that critically modulate neuronal activity. Four HCN subunits (HCN1–4) have …
The hyperpolarization-activated cyclic nucleotide–gated channels: from biophysics to pharmacology of a unique family of ion channels
L Sartiani, G Mannaioni, A Masi, MN Romanelli… - Pharmacological …, 2017 - Elsevier
Hyperpolarization-activated, cyclic nucleotide–gated (HCN) channels are important
members of the voltage-gated pore loop channels family. They show unique features: they …
members of the voltage-gated pore loop channels family. They show unique features: they …
Cardiac and neuronal HCN channelopathies
I Rivolta, A Binda, A Masi, JC DiFrancesco - Pflügers Archiv-European …, 2020 - Springer
Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …
Selective HCN1 block as a strategy to control oxaliplatin-induced neuropathy
Abstract Chemotherapy-Induced Peripheral Neuropathy (CIPN) is the most frequent adverse
effect of pharmacological cancer treatments. The occurrence of neuropathy prevents the …
effect of pharmacological cancer treatments. The occurrence of neuropathy prevents the …
Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1
Herpes simplex virus-1 (HSV-1) establishes a latent infection in neurons and periodically
reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully …
reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully …
The HCN channel as a pharmacological target: Why, where, and how to block it
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels, expressed in a variety
of cell types and in all tissues, control excitation and rhythm. Since their discovery in neurons …
of cell types and in all tissues, control excitation and rhythm. Since their discovery in neurons …
Are ion channels potential therapeutic targets for Parkinson's disease?
NH Daniel, A Aravind, P Thakur - Neurotoxicology, 2021 - Elsevier
Parkinson's disease (PD) is primarily associated with the progressive neurodegeneration of
the dopaminergic neurons in the substantia nigra region of the brain. The resulting motor …
the dopaminergic neurons in the substantia nigra region of the brain. The resulting motor …