Disease stratification in GCA and PMR: state of the art and future perspectives

A Tomelleri, KSM van der Geest, MA Khurshid… - Nature Reviews …, 2023 - nature.com
Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are closely related conditions
characterized by systemic inflammation, a predominant IL-6 signature, an excellent …

Giant cell arteritis: Update on clinical manifestations, diagnosis, and management

N Farina, A Tomelleri, C Campochiaro… - European Journal of …, 2023 - Elsevier
Giant cell arteritis (GCA) is the most common vasculitis affecting people older than 50 years.
The last decades have shed new light on the clinical paradigm of this condition, expanding …

Probability-based algorithm using ultrasound and additional tests for suspected GCA in a fast-track clinic

A Sebastian, A Tomelleri, A Kayani, D Prieto-Pena… - RMD open, 2020 - rmdopen.bmj.com
Objectives Clinical presentations of giant cell arteritis (GCA) are protean, and it is vital to
make a secure diagnosis and exclude mimics for urgent referrals with suspected GCA. The …

Quantitative ultrasound to monitor the vascular response to tocilizumab in giant cell arteritis

L Seitz, L Christ, F Lötscher, G Scholz, AC Sarbu… - …, 2021 - academic.oup.com
Objectives To characterize the effect of ultra-short glucocorticoids followed by Tocilizumab
monotherapy on the intima-media thickness (IMT) in GCA. Methods Eighteen GCA patients …

Imaging tests in the early diagnosis of giant cell arteritis

D Prieto-Pena, S Castaneda… - Journal of Clinical …, 2021 - mdpi.com
Early recognition of giant cell arteritis (GCA) is crucial to avoid the development of ischemic
vascular complications, such as blindness. The classic approach to making the diagnosis of …

Role of the halo sign in the assessment of giant cell arteritis: a systematic review and meta-analysis

A Sebastian, F Coath, S Innes, J Jackson… - … advances in practice, 2021 - academic.oup.com
Objectives This systematic review and meta-analysis aimed to evaluate the diagnostic value
of the halo sign in the assessment of GCA. Methods A systematic literature review was …

Disease stratification in giant cell arteritis to reduce relapses and prevent long-term vascular damage

A Tomelleri, KSM van der Geest… - The Lancet …, 2021 - thelancet.com
For years, clinicians and researchers working on giant cell arteritis have been battling with
the conundrum of a disease that displays a short-term steroid responsiveness but is …

Development of a diagnostic prediction model for giant cell arteritis by sequential application of Southend Giant Cell Arteritis Probability Score and ultrasonography: a …

A Sebastian, KSM van der Geest… - The Lancet …, 2024 - thelancet.com
Background Giant cell arteritis is a critically ischaemic disease with protean manifestations
that require urgent diagnosis and treatment. European Alliance of Associations for …

Efficacy of leflunomide as a steroid‐sparing agent in treatment of Indian giant cell arteritis patients: a 2‐year follow‐up study

S Das, RP Goswami, D Sinha, A Ghosal… - International Journal …, 2022 - Wiley Online Library
Objectives To evaluate the effectiveness of leflunomide as a steroid‐sparing agent among
Indian patients with giant cell arteritis (GCA) and to assess the changes of “halo sign” within …

Vascular ultrasound as a follow-up tool in patients with giant cell arteritis: a prospective observational cohort study

ACB Haaversen, LK Brekke, TA Kermani… - Frontiers in …, 2024 - frontiersin.org
Objectives To evaluate relapses in giant cell arteritis (GCA), investigate the utility of vascular
ultrasound to detect relapses, and develop and assess a composite score for GCA disease …