Anticancer activity of novel 3‐(furan‐2‐yl) pyrazolyl and 3‐(thiophen‐2‐yl) pyrazolyl hybrid chalcones: Synthesis and in vitro studies

MT Helmy, FM Sroor, KF Mahrous… - Archiv der …, 2022 - Wiley Online Library
Twelve novel chalcone derivatives were prepared using the Claisen–Schmidt condensation
reaction. The reaction of 4‐acetyl‐5‐furan/thiophene‐pyrazole derivatives 5 with the …

Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1, 2-dihydroquinolin-3-yl) methylene)-2-phenyloxazol-5 (4H)-one

EA Ghareeb, NFH Mahmoud, EA El-Bordany… - Bioorganic …, 2021 - Elsevier
A new series of nitrogen heterocycles encompassing a quinoline scaffold such as
imidazolone, benzimidazole, triazinone, triazole, and thiazole derivatives was synthesized …

Synthesis, antiproliferative activity, and molecular docking of some N‐heterocycles bearing a pyrazole scaffold against liver and breast tumors

SK Ramadan, AK El‐Ziaty, RS Ali - Journal of Heterocyclic …, 2021 - Wiley Online Library
A new series of some 1, 3‐diphenylpyrazole‐based heterocycles were constructed from 2‐
cyano‐3‐(1, 3‐diphenyl‐1 H‐pyrazol‐4‐yl) propenoyl chloride (1). The titled acid chloride …

New potential fungicides pyrazole-based heterocycles derived from 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl) acryloyl isothiocyanate

SK Ramadan, NA Ibrahim, SA El-Kaed… - Journal of Sulfur …, 2021 - Taylor & Francis
New series of pyrazole-based heterocyclic systems were synthesized using 2-
cyanopropenoyl isothiocyanate derivative as an intermediate through treating with some …

Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

Synthesis and biological activity on IBD virus of diverse heterocyclic systems derived from 2-cyano-N'-((2-oxo-1,2-dihydroquinolin-3-yl)methylene)acetohydrazide

MM Kaddah, ARI Morsy, AA Fahmi… - Synthetic …, 2021 - Taylor & Francis
Abstract A 2-cyano-N'-((2-oxo-1, 2-dihydroquinolin-3-yl) methylene) ethanohydrazide (3)
was synthesized in 87% yield via condensation of 3-formyl-2-oxoquinoline (1) with 2 …

Ultrasonic promoted regioselective reactions of the novel spiro 3, 1-benzoxazon-isobenzofuranone dye toward some organic base reagents

AI Hassaballah, SK Ramadan, SA Rizk… - Polycyclic Aromatic …, 2023 - Taylor & Francis
Ultrasonic and solvent-free condensation of 2-aminobenzoic acid with 4-
bromoisobenzofuran-1, 3-dione to construct the 4′-bromo-3′ H-spiro [benzo [d][1, 3] …

3-Aryl/hetaryl-2-cyanoacryloyl chlorides: Synthesis and reactions with binucleophiles targeting heterocycles

EAE El-Helw, AK El-Ziaty - Egyptian Journal of Chemistry, 2022 - journals.ekb.eg
In this review, we reported the synthetic method used to construct thirteen derivatives of 3-
aryl/heteryl-2-cyanoacryloyl chloride followed by a focused survey on their spectral data and …

Synthesis, DFT and Antitumor Activity Screening of Some New Heterocycles Derived from 2,2'-(2-(1,3-Diphenyl-1H-Pyrazol-4-yl)Ethene-1,1-Diyl)Bis(4H-Benzo[d][1 …

AM Abdelrahman, AA Fahmi, SA Rizk… - Polycyclic Aromatic …, 2023 - Taylor & Francis
The broad spectrum of biological activity of pyrazole derivatives coupled with our interest in
the chemistry of nitrogen heterocycles led us to synthesize a bis-benzoxazinone derivative …

Acryloyl isothiocyanate skeleton as a precursor for synthesis of some novel pyrimidine, triazole, triazepine, thiadiazolopyrimidine and acylthiourea derivatives as …

AA El-Badawy, AS Elgubbi… - Journal of Sulfur …, 2021 - Taylor & Francis
ABSTRACT The reactions of 2-cyano-3-pyrazolylpropenoyl isothiocyanate derivative 2 with
some mono-and bidentate nucleophiles namely, dodecan-1-amine, 6-aminothiouracil …