Ever since loss of survival motor neuron (SMN) protein was identified as the direct cause of
the childhood inherited neurodegenerative disorder spinal muscular atrophy, significant …

Spatial organization of cellular processes in membranous or membrane-less organelles
(MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical …

In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO)
target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins …

Distal hereditary neuropathies and neuro motor diseases are complex neurological
phenotypes associated with pathogenic variants in a large number of genes, but in some the …

Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Cajal is commonly regarded as the father of modern neuroscience in recognition of his
fundamental work on the structure of the nervous system. But Cajal also made seminal …

The WRAP53 gene encodes both an antisense transcript (WRAP53α) that stabilizes the
tumor suppressor p53 and a protein (WRAP53β) involved in maintenance of Cajal bodies …

Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease with
dysfunctional α-motor neurons in the anterior horn of the spinal cord. SMA is caused by loss …

Survival motor neuron protein (SMN), which is linked to spinal muscular atrophy, is a key
component of the Gemin complex, which is essential for the assembly of small nuclear RNA …

Spinal Muscular Atrophy (SMA) is a neuromuscular disorder caused by mutations in the
SMN1 gene. Being a monogenic disease, it is characterized by high clinical heterogeneity …