Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Over the past two decades there has been a great deal of interest in the development of
inhibitors of the cyclin-dependent kinases (CDKs). This attention initially stemmed from …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The Mediator complex is a multi-subunit assembly that appears to be required for regulating
expression of most RNA polymerase II (pol II) transcripts, which include protein-coding and …

Cyclins and cyclin-dependent protein kinases (CDKs) are important regulatory components
that are required for cell cycle progression. The levels of the cell cycle CDKs are generally …

The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite
the importance of HIF1A in homeostasis and various pathologies, little is known about how it …

Mediator is an essential, large, multisubunit, transcriptional co-activator highly conserved
across eukaryotes. Mediator interacts with gene-specific transcription factors at enhancers …

Colon tumors arise in a stepwise fashion from either discrete genetic perturbations or
epigenetic dysregulation. To uncover the key epigenetic regulators that drive colon cancer …

The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …