Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Cytisine, a natural bioactive compound that is mainly isolated from plants of the
Leguminosae family (especially the seeds of Laburnum anagyroides), has been marketed in …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

The integrated stress response (ISR) is a highly conserved biochemical pathway that
regulates protein synthesis. The ISR is activated in response to diverse stressors to restore …

Accumulating evidence suggests that CNS α7 nicotinic acetylcholine receptors (nAChRs)
are important targets for the development of therapeutic approaches for Parkinson's disease …

Proper lipid metabolism is crucial to maintain alveolar epithelial cell (AEC) function, and
excessive AEC death plays a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) …

The number of nicotinic acetylcholine receptors (AChRs) present in the plasma membrane
of muscle and neuronal cells is limited by the assembly of individual subunits into mature …

Upregulation of neuronal nicotinic acetylcholine receptors (AChRs) is a venerable result of
chronic exposure to nicotine; but it is one of several consequences of pharmacological …

Upregulation of β2 subunit-containing (β2*) nicotinic acetylcholine receptors (nAChRs) is
implicated in several aspects of nicotine addiction, and menthol cigarette smokers tend to …