Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Modeling inflammation in zebrafish for the development of anti-inflammatory drugs

Y Xie, AH Meijer, MJM Schaaf - Frontiers in cell and developmental …, 2021 - frontiersin.org
Dysregulation of the inflammatory response in humans can lead to various inflammatory
diseases, like asthma and rheumatoid arthritis. The innate branch of the immune system …

Infection of zebrafish embryos with intracellular bacterial pathogens

EL Benard, AM van der Sar, F Ellett… - JoVE (Journal of …, 2012 - jove.com
Zebrafish (Danio rerio) embryos are increasingly used as a model for studying the function
of the vertebrate innate immune system in host-pathogen interactions 1. The major cell types …

Zebrafish embryos and larvae: a new generation of disease models and drug screens

S Ali, DL Champagne, HP Spaink… - … Research Part C …, 2011 - Wiley Online Library
Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Host-pathogen interactions made transparent with the zebrafish model

AH Meijer, HP Spaink - Current drug targets, 2011 - ingentaconnect.com
The zebrafish holds much promise as a high-throughput drug screening model for immune-
related diseases, including inflammatory and infectious diseases and cancer. This is due to …

Zebrafish xenografts as a tool for in vivo studies on human cancer

M Konantz, TB Balci, UF Hartwig… - Annals of the New …, 2012 - Wiley Online Library
The zebrafish has become a powerful vertebrate model for genetic studies of embryonic
development and organogenesis and increasingly for studies in cancer biology. Zebrafish …

Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model

V Torraca, S Masud, HP Spaink… - Disease models & …, 2014 - journals.biologists.com
Studying macrophage biology in the context of a whole living organism provides unique
possibilities to understand the contribution of this extremely dynamic cell subset in the …

Seasonal changes and respiratory deposition flux of PM2. 5 and PM10 bound metals in Dhaka, Bangladesh

M Moniruzzaman, MAA Shaikh, B Saha, S Shahrukh… - Chemosphere, 2022 - Elsevier
Due to rapid urbanization and fast economic development, aerosol pollution is a serious
environmental issue, especially in Bangladesh. Based on bioaccessibility and respiratory …

Pathogen recognition and activation of the innate immune response in zebrafish

M van der Vaart, HP Spaink… - Advances in …, 2012 - Wiley Online Library
The zebrafish has proven itself as an excellent model to study vertebrate innate immunity. It
presents us with possibilities for in vivo imaging of host‐pathogen interactions which are …

Neutrophils in host defense: new insights from zebrafish

EA Harvie, A Huttenlocher - Journal of Leucocyte Biology, 2015 - academic.oup.com
Neutrophils are highly motile phagocytic cells that play a critical role in the immune
response to infection. Zebrafish (Danio rerio) are increasingly used to study neutrophil …