Nuclear architecture—the spatial arrangement of chromosomes and other nuclear
components—provides a framework for organizing and regulating the diverse functional …

In this post-genomic era, we need to define gene function on a genome-wide scale for
model organisms and humans. The fundamental unit of biological processes is the cell …

Abstract The neXtProt knowledgebase (https://www. nextprot. org) is an integrative resource
providing both data on human protein and the tools to explore these. In order to provide …

Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

Imaging techniques such as immunofluorescence (IF) and the expression of fluorescent
protein (FP) fusions are widely used to investigate the subcellular distribution of proteins …

The neXtProt human protein knowledgebase (https://www. nextprot. org) continues to add
new content and tools, with a focus on proteomics and genetic variation data. neXtProt now …

RNA interference (RNAi) is a powerful tool to study gene function in cultured cells.
Transfected cell microarrays in principle allow high-throughput phenotypic analysis after …

Cellular processes depend on the fidelity of intracellular membrane traffic. Lipids, proteins,
receptor ligands and solute molecules are trafficked to distinct compartments within the cell …

Elevated plasma cholesterol levels are considered responsible for excess cardiovascular
morbidity and mortality. Cholesterol in plasma is tightly controlled by cholesterol within cells …

Abstract neXtProt (http://www. nextprot. org/) is a new human protein-centric knowledge
platform. Developed at the Swiss Institute of Bioinformatics (SIB), it aims to help researchers …