Modelling adult diseases to understand their aetiology and progression, and to develop new
therapies, is a major challenge for medical biology. We are excited by new efforts in the …

Melanocytes derived from neural crest cells harbor the BRAFV600E mutation, which is the
predominant driver of nevus formation in humans. This mutation leads to malignant cell …

ABSTRACT International Women's Day 2024 has a theme of inclusion. As publishers of
preclinical research, we aim to show how inclusion of females in research advances …

Keratinocytes, the dominant cell type in the melanoma microenvironment during tumor
initiation, exhibit diverse effects on melanoma progression. Using a zebrafish model of …

Offspring sex ratio has been proposed as an indicator of the risk of developing certain
cancers in humans, but offspring sex ratio may also be a consequence of the disease. In this …

The World Health Organization (WHO) has recently reported that more than 39% of adults
are currently overweight or obese, globally, raising concerns for the prevalence of obesity …