FAK signaling in human cancer as a target for therapeutics
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …
mediated signals, governing fundamental processes in normal and cancer cells through its …
Signal transduction by focal adhesion kinase in cancer
J Zhao, JL Guan - Cancer and Metastasis Reviews, 2009 - Springer
Cellular interactions with extracellular matrix play essential roles in tumor initiation,
progression and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase …
progression and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase …
[HTML][HTML] Targeting FAK in human cancer: from finding to first clinical trials
VM Golubovskaya - Frontiers in bioscience (Landmark edition), 2014 - ncbi.nlm.nih.gov
It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …
Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis
MK Wendt, WP Schiemann - Breast cancer research, 2009 - Springer
Introduction Mammary tumorigenesis is associated with the increased expression of several
proteins in the focal adhesion complex, including focal adhesion kinase (FAK) and various …
proteins in the focal adhesion complex, including focal adhesion kinase (FAK) and various …
Focal adhesion kinase and cancer
VM Golubovskaya, FA Kweh… - Histology and …, 2009 - digitum.um.es
Focal adhesion kinase (FAK) is a nonreceptor tyrosine kinase that resides at the sites of
integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of …
integrin clustering, known as focal adhesions. The FAK protein has a molecular mass of …
[HTML][HTML] CRISPR/Cas9: a powerful tool for identification of new targets for cancer treatment
Highlights•CRISPR/Cas9 has been widely used for the identification of potential therapeutic
targets in cancer.•Several potential targets such as CD38, CXCR2, MASTL and RBX2 have …
targets in cancer.•Several potential targets such as CD38, CXCR2, MASTL and RBX2 have …
[HTML][HTML] Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway
W Masraksa, S Tanasawet… - Nutrition Research …, 2020 - synapse.koreamed.org
RESULTS Administration with up to 40 µM luteolin showed no cytotoxic activity on lung
cancer A549 cells or non-cancer MRC-5 cells. Additionally, luteolin at 20–40 µM significantly …
cancer A549 cells or non-cancer MRC-5 cells. Additionally, luteolin at 20–40 µM significantly …
Focal adhesion kinase as a cancer therapy target
VM Golubovskaya - Anti-Cancer Agents in Medicinal …, 2010 - ingentaconnect.com
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that resides at the sites of at
focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human …
focal adhesions. The 125 kDa FAK protein is encoded by the FAK gene located on human …
[HTML][HTML] Fucoidan inhibition of lung cancer in vivo and in vitro: Role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation
Fucoidan, a polysaccharide extracted from brown seaweeds, reduces tumor cell
proliferation. In this study, we demonstrate that fucoidan reduces tumor size in LLC1 …
proliferation. In this study, we demonstrate that fucoidan reduces tumor size in LLC1 …
miR-151a induces partial EMT by regulating E-cadherin in NSCLC cells
I Daugaard, KJ Sanders, A Idica, K Vittayarukskul… - Oncogenesis, 2017 - nature.com
Abstract miR-151a and its host gene, focal adhesion kinase, FAK, are located in a region of
chromosome 8q that is frequently amplified in solid tumors, including lung cancer. Lung …
chromosome 8q that is frequently amplified in solid tumors, including lung cancer. Lung …