BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

The ability of cells to respond to mechanical forces is critical for numerous biological
processes. Emerging evidence indicates that external mechanical forces trigger changes in …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

Cells sense mechanical signals from their microenvironment and transduce them to the
nucleus to regulate gene expression programs. To elucidate the physical mechanisms …

Cellular behavior is continuously affected by microenvironmental forces through the process
of mechanotransduction, in which mechanical stimuli are rapidly converted to biochemical …

Cultured meat has potential to diversify methods for protein production, but innovations in
production efficiency will be required to make cultured meat a feasible protein alternative …

The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton …

A robust nanopillar platform with increased spatial resolution reveals that perinuclear forces,
originating from stress fibres spanning the nucleus of fibroblasts, are significantly higher on …

Mechanical forces transduced to cells through the extracellular matrix are critical regulators
of tissue development, growth, and homeostasis, and can play important roles in directing …