The evolution of SARS-CoV-2

PV Markov, M Ghafari, M Beer, K Lythgoe… - Nature Reviews …, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …

Persistent SARS-CoV-2 infection: significance and implications

HM Machkovech, AM Hahn, JG Wang… - The Lancet Infectious …, 2024 - thelancet.com
SARS-CoV-2 causes persistent infections in a subset of individuals, which is a major clinical
and public health problem that should be prioritised for further investigation for several …

Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA. 1 and BA. 2 receptor-binding domains

TN Starr, AJ Greaney, CM Stewart, AC Walls… - PLoS …, 2022 - journals.plos.org
SARS-CoV-2 continues to acquire mutations in the spike receptor-binding domain (RBD)
that impact ACE2 receptor binding, folding stability, and antibody recognition. Deep …

Deep mutational scans of XBB. 1.5 and BQ. 1.1 reveal ongoing epistatic drift during SARS-CoV-2 evolution

AL Taylor, TN Starr - PLoS Pathogens, 2023 - journals.plos.org
Substitutions that fix between SARS-CoV-2 variants can transform the mutational landscape
of future evolution via epistasis. For example, large epistatic shifts in mutational effects …

Translating insights into therapies for Long Covid

AAR Antar, AL Cox - Science translational medicine, 2024 - science.org
Long Covid is defined by a wide range of symptoms that persist after the acute phase of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Commonly …

[HTML][HTML] Wastewater surveillance of SARS-CoV-2 variants in October–November 2022 in Italy: detection of XBB. 1, BA. 2.75 and rapid spread of the BQ. 1 lineage

G La Rosa, D Brandtner, GB Ferraro, C Veneri… - Science of the Total …, 2023 - Elsevier
This study adds insight regarding the occurrence and spread of SARS-CoV-2 Variants of
Concern (VOCs) and Variants of Interest (VOIs) in Italy in October and November 2022, by …

Regional reemergence of a SARS-CoV-2 Delta lineage amid an Omicron wave detected by wastewater sequencing

A Haver, R Theijn, ID Grift, G Raaijmakers, E Poorter… - Scientific Reports, 2023 - nature.com
The implementation and integration of wastewater-based epidemiology constitutes a
valuable addition to existing pathogen surveillance systems, such as clinical surveillance for …

Detection of human adenovirus F41 in wastewater and its relationship to clinical cases of acute hepatitis of unknown aetiology

MI Reyne, DM Allen, A Levickas, P Allingham… - Science of the Total …, 2023 - Elsevier
Abstract As of 8 July 2022, the World Health Organization (WHO) have reported 1010
probable cases of acute hepatitis of unknown aetiology in children worldwide, including …

Wastewater genomic sequencing for SARS-CoV-2 variants surveillance in wastewater-based epidemiology applications

X Xu, Y Deng, J Ding, X Zheng, C Wang, D Wang, L Liu… - Water Research, 2023 - Elsevier
Wastewater-based epidemiology (WBE) has been widely used as a complementary
approach to SARS-CoV-2 clinical surveillance. Wastewater genomic sequencing could …

The consequences of SARS-CoV-2 within-host persistence

A Sigal, RA Neher, RJ Lessells - Nature Reviews Microbiology, 2024 - nature.com
SARS-CoV-2 causes an acute respiratory tract infection that resolves in most people in less
than a month. Yet some people with severely weakened immune systems fail to clear the …