Background Extensive evidence shows that well over 50% of people prefer to be cared for
and to die at home provided circumstances allow choice. Despite best efforts and policies …

Polypharmacy is a highly prevalent problem in older persons, and is challenging to assess
and improve due to variations in definitions of the problem and the heterogeneous methods …

Importance For patients with limited prognosis, some medication risks may outweigh the
benefits, particularly when benefits take years to accrue; statins are one example. Data are …

Objective: Many older adults cope with various chronic physical health conditions, and in
some cases, with mental health and/or cognitive difficulties. Mindfulness-based interventions …

Purpose The anesthetic ketamine is widely used for pain related to cancer, but the evidence
to support its use in this setting is weak. This study aimed to determine whether ketamine is …

Polypharmacy is a well known problem in elderly patients in general, but its prevalence and
effects in patients with cancer are less clear, particularly in end-of-life settings. This Review …

Background Overuse of unnecessary medications in frail older adults with limited life
expectancy remains an understudied challenge. Objective To identify intervention studies …

Context Patients with advanced illness are prescribed multiple medications in the last year
of life, intensifying the risk of negative consequences related to polypharmacy. Objectives To …

Purpose Polypharmacy has been associated with drug–drug interactions, adverse drug
events, hospitalisation and increased mortality. The purpose of this study was to investigate …

OBJECTIVES: To evaluate the feasibility of developing consensus recommendations for
appropriate prescribing for patients with advanced dementia using a new conceptual …