Adenosine as a multi-signalling guardian angel in human diseases: when, where and how does it exert its protective effects?
The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
nucleoside is an integral component of ATP, and regulates the function of every tissue and …
Historical and current adenosine receptor agonists in preclinical and clinical development
KA Jacobson, DK Tosh, S Jain, ZG Gao - Frontiers in cellular …, 2019 - frontiersin.org
Adenosine receptors (ARs) function in the body's response to conditions of pathology and
stress associated with a functional imbalance, such as in the supply and demand of …
stress associated with a functional imbalance, such as in the supply and demand of …
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …
agents to treat neuropathic pain,. However, development of analgesic orthosteric A1R …
Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief
Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-
binding protein (G protein)–coupled receptors (GPCRs) control many pathophysiological …
binding protein (G protein)–coupled receptors (GPCRs) control many pathophysiological …
A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain
Nanoparticle-mediated drug delivery is especially useful for targets within endosomes
because of the endosomal transport mechanisms of many nanomedicines within cells. Here …
because of the endosomal transport mechanisms of many nanomedicines within cells. Here …
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission
G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma
membrane, where they interact with extracellular ligands and couple to G proteins that …
membrane, where they interact with extracellular ligands and couple to G proteins that …
Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a
Human genetic studies have implicated the voltage-gated sodium channel NaV1. 7 as a
therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated …
therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated …
Treatment of chronic neuropathic pain: purine receptor modulation
Extracellular nucleosides and nucleotides have widespread functions in responding to
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …
physiological stress. The “purinome” encompasses 4 G-protein-coupled receptors (GPCRs) …
[HTML][HTML] Adenosine receptors: Emerging non-opioids targets for pain medications
Physical and emotional pain deteriorates the quality of well-being. Also, numerous non-
invasive and invasive treatments for diagnosed diseases such as cancer medications and …
invasive and invasive treatments for diagnosed diseases such as cancer medications and …
Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A1 Receptor
Despite intense interest in designing positive allosteric modulators (PAMs) as selective
drugs of the adenosine A1 receptor (A1AR), structural binding modes of the receptor PAMs …
drugs of the adenosine A1 receptor (A1AR), structural binding modes of the receptor PAMs …