Reelin functions, mechanisms of action and signaling pathways during brain development and maturation

Y Jossin - Biomolecules, 2020 - mdpi.com
During embryonic development and adulthood, Reelin exerts several important functions in
the brain including the regulation of neuronal migration, dendritic growth and branching …

Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

The functions of Reelin in membrane trafficking and cytoskeletal dynamics: implications for neuronal migration, polarization and differentiation

J Santana, MP Marzolo - Biochemical Journal, 2017 - portlandpress.com
Reelin is a large extracellular matrix protein with relevant roles in mammalian central
nervous system including neurogenesis, neuronal polarization and migration during …

Understanding SOCS protein specificity

EM Linossi, DJ Calleja, SE Nicholson - Growth Factors, 2018 - Taylor & Francis
The development and activity of our immune system are largely controlled by the action of
pleiotropic cytokines and growth factors, small secreted proteins, which bind to receptors on …

Circular RNA circ_103820 suppresses lung cancer tumorigenesis by sponging miR-200b-3p to release LATS2 and SOCS6

Y Chi, W Zheng, G Bao, L Wu, X He, R Gan… - Cell Death & …, 2021 - nature.com
A growing number of circular RNAs (circRNAs) have been identified and verified in several
cancers. However, highly efficient therapeutic methods based on circRNAs in lung cancer …

Mllt11 regulates migration and neurite outgrowth of cortical projection neurons during development

D Stanton-Turcotte, K Hsu, SA Moore… - Journal of …, 2022 - Soc Neuroscience
The formation of connections within the mammalian neocortex is highly regulated by both
extracellular guidance mechanisms and intrinsic gene expression programs. There are two …

[HTML][HTML] Zebrafish suppressor of cytokine signaling 4b (Socs4b) is dispensable for development but may regulate epidermal growth factor receptor signaling

M Trengove, P Rasighaemi, C Liongue, AC Ward - Biomolecules, 2024 - mdpi.com
The suppressor of cytokine signaling (SOCS) family of proteins were named after their
defining role as negative feedback regulators of signaling initiated by numerous cytokine …

Methyltransferase-like 3 facilitates lung cancer progression by accelerating m6A methylation-mediated primary miR-663 processing and impeding SOCS6 expression

S Li, X Lu, D Zheng, W Chen, Y Li, F Li - Journal of Cancer Research and …, 2022 - Springer
Objective Lung cancer (LC) remains a threatening health issue worldwide.
Methyltransferase-like protein 3 (METTL3) is imperative in carcinogenesis via m6A …

[HTML][HTML] Sex-Specific Behavioral and Molecular Responses to Maternal Lipopolysaccharide-Induced Immune Activation in a Murine Model: Implications for …

J Xu, R Zhao, M Yan, M Zhou, H Liu, X Wang… - International Journal of …, 2024 - mdpi.com
Maternal immune activation (MIA) during pregnancy has been increasingly recognized as a
critical factor in the development of neurodevelopmental disorders, with potential sex …

Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson–Forssman–Lehmann …

HM McRae, MPY Leong, MI Bergamasco… - PLoS …, 2024 - journals.plos.org
Börjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked intellectual disability and
endocrine disorder caused by pathogenic variants of plant homeodomain finger gene 6 …