Astrocyte-neuron metabolic crosstalk in neurodegeneration: a mitochondrial perspective

P Mulica, A Grünewald, SL Pereira - Frontiers in endocrinology, 2021 - frontiersin.org
Converging evidence made clear that declining brain energetics contribute to aging and are
implicated in the initiation and progression of neurodegenerative disorders such as …

Glia: a major player in glutamate–GABA dysregulation‐mediated neurodegeneration

A Sood, K Preeti, V Fernandes… - Journal of …, 2021 - Wiley Online Library
The imbalance between glutamate and γ‐aminobutyric acid (GABA) results in the loss of
synaptic strength leading to neurodegeneration. The dogma on the field considered neurons …

The plasma metabolome of long COVID patients two years after infection

Y López-Hernández, J Monárrez-Espino, DAG López… - Scientific reports, 2023 - nature.com
One of the major challenges currently faced by global health systems is the prolonged
COVID-19 syndrome (also known as “long COVID”) which has emerged as a consequence …

The gut microbiota affects the social network of honeybees

J Liberti, T Kay, A Quinn, L Kesner, ET Frank… - Nature ecology & …, 2022 - nature.com
The gut microbiota influences animal neurodevelopment and behaviour but has not
previously been documented to affect group-level properties of social organisms. Here, we …

Identification of metabolites reproducibly associated with Parkinson's Disease via meta-analysis and computational modelling

X Luo, Y Liu, A Balck, C Klein, RMT Fleming - npj Parkinson's Disease, 2024 - nature.com
Many studies have reported metabolomic analysis of different bio-specimens from
Parkinson's disease (PD) patients. However, inconsistencies in reported metabolite …

Human astrocytes model derived from induced pluripotent stem cells

N Leventoux, S Morimoto, K Imaizumi, Y Sato… - Cells, 2020 - mdpi.com
Induced pluripotent stem cell (iPSC)-based disease modeling has a great potential for
uncovering the mechanisms of pathogenesis, especially in the case of neurodegenerative …

Astrocytes: dissecting their diverse roles in amyotrophic lateral sclerosis and frontotemporal dementia

CF Valori, C Sulmona, L Brambilla, D Rossi - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal
neurodegenerative disorders often co-occurring in the same patient, a feature that suggests …

[HTML][HTML] Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

A Chandrasekaran, KS Dittlau, GI Corsi, H Haukedal… - Stem cell reports, 2021 - cell.com
Summary Frontotemporal dementia type 3 (FTD3), caused by a point mutation in the
charged multivesicular body protein 2B (CHMP2B), affects mitochondrial ultrastructure and …

Neuroactive metabolites modulated by the gut microbiota in honey bees

A Cabirol, S Moriano‐Gutierrez… - Molecular …, 2023 - Wiley Online Library
Honey bees have emerged as a new model to study the gut–brain axis, as they exhibit
complex social behaviors and cognitive abilities, while experiments with gnotobiotic bees …

The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings

A Chaves‐Filho, C Eyres, L Blöbaum… - Journal of …, 2024 - Wiley Online Library
Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …