The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium‐derived …

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has
quickly become a worldwide pandemic with few tangible and safe treatment options …

Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the
development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is …

Abstract Endothelin-1 (ET-1) is involved in the regulation of a myriad of processes highly
relevant for physical and mental well-being; female and male health; in the modulation of …

Insulin has an exercise-like action to increase microvascular perfusion of skeletal muscle
and thereby enhance delivery of hormone and nutrient to the myocytes. With insulin …

Endothelin (ET)-1-mediated vasoconstrictor tone contributes to the development and
progression of several adiposity-related conditions, including hypertension and …

Obesity dramatically increases the risk of development of cardiovascular and metabolic
diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs …

Background and aims Habitual short nightly sleep duration is associated with increased
atherosclerotic cardiovascular disease risk and morbidity. Vascular endothelial dysfunction …

Endothelin-1 (ET-1) contributes to vascular dysfunction in postmenopausal women (PMW).
Although aerobic exercise is beneficial in reducing ET-1-mediated vasoconstrictor tone in …