A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?

X Cao, L Ding, Z Xie, Y Yang, M Whiteman… - Antioxidants & redox …, 2019 - liebertpub.com
Abstract Significance: Hydrogen sulfide (H2S) has been recognized as the third gaseous
transmitter alongside nitric oxide and carbon monoxide. In the past decade, numerous …

Recent development of the molecular and cellular mechanisms of hydrogen sulfide gasotransmitter

J Liu, FM Mesfin, CE Hunter, KR Olson, WC Shelley… - Antioxidants, 2022 - mdpi.com
Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along
with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on …

[HTML][HTML] Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3

HJ Sun, SP Xiong, X Cao, L Cao, MY Zhu, ZY Wu… - Redox biology, 2021 - Elsevier
Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage
renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are …

Gas and gas-generating nanoplatforms in cancer therapy

YZ Jing, SJ Li, ZJ Sun - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
Gas therapy is the usage of certain gases with special therapeutic effects for the treatment of
diseases. Hydrogen (H2), nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide …

Hydrogen sulfide and carnosine: modulation of oxidative stress and inflammation in kidney and brain axis

V Calabrese, M Scuto, AT Salinaro, G Dionisio… - Antioxidants, 2020 - mdpi.com
Emerging evidence indicates that the dysregulation of cellular redox homeostasis and
chronic inflammatory processes are implicated in the pathogenesis of kidney and brain …

Autophagy and necroptosis in cisplatin-induced acute kidney injury: Recent advances regarding their role and therapeutic potential

N Alassaf, H Attia - Frontiers in Pharmacology, 2023 - frontiersin.org
Cisplatin (CP) is a broad-spectrum antineoplastic agent, used to treat many different types of
malignancies due to its high efficacy and low cost. However, its use is largely limited by …

Hydrogen sulfide and the kidney: physiological roles, contribution to pathophysiology, and therapeutic potential

M Peleli, P Zampas… - Antioxidants & Redox …, 2022 - liebertpub.com
Significance: Hydrogen sulfide (H2S), the third member of the gasotransmitter family, has a
broad spectrum of biological activities, including antioxidant and cytoprotective actions, as …

S-sulfhydration of SIRT3 by hydrogen sulfide attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury

Y Yuan, L Zhu, L Li, J Liu, Y Chen, J Cheng… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Clinical use of cisplatin (Cisp), one of the most widely used, common, and effective
chemotherapeutic agents, is limited by its side effects, particularly tubular injury-associated …

A Trisulfide Bond Containing Biodegradable Polymer Delivering Pt(IV) Prodrugs to Deplete Glutathione and Donate H2S to Boost Chemotherapy and Antitumor …

X Li, J Cai, H Zhang, S Sun, S Zhao, Z Wang, X Nie… - ACS …, 2024 - ACS Publications
The clinical application of cisplatin (CisPt) is limited by its dose-dependent toxicity. To
overcome this, we developed reduction-responsive nanoparticles (NP (3S) s) for the …

Therapeutic potential of sulfur-containing natural products in inflammatory diseases

X Cao, L Cao, W Zhang, R Lu, JS Bian, X Nie - Pharmacology & …, 2020 - Elsevier
Owing to the prevalence of chronic inflammation and its related disorders, there is a demand
for novel therapeutic agents capable of preventing or suppressing inflammation. Natural …