Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

Voltage-gated sodium channels initiate action potentials in nerve, skeletal muscle, and other
electrically excitable cells. Mutations in them cause a wide range of diseases. These …

Dravet syndrome is a severe epileptic encephalopathy, characterized by (febrile) seizures,
behavioural problems and developmental delay. Eighty per cent of patients with Dravet …

Abstract NBI-921352 (formerly XEN901) is a novel sodium channel inhibitor designed to
specifically target Na V 1.6 channels. Such a molecule provides a precision-medicine …

There remains an urgent need for new therapies for treatment-resistant epilepsy. Sodium
channel blockers are effective for seizure control in common forms of epilepsy, but loss of …

Dravet syndrome is an intractable developmental and epileptic encephalopathy caused by
de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium …

Genetic epilepsy occurs as a result of mutations in either a single gene or an interplay of
different genes. These mutations have been detected in ion channel and non-ion channel …

Inherited and sporadic mutations in genes encoding for brain ion channels, affecting
membrane expression or biophysical properties, have been associated with …

Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in
regulating eukaryotic cellular processes and maintaining homeostasis, making it …

A key unanswered question in migraine neurobiology concerns the mechanisms that make
the brain of migraineurs susceptible to cortical spreading depression (CSD, a spreading …