Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in
response to activation of many different G protein-coupled receptors and thus control the …

G protein-gated K+ channels (Kir3. 1–Kir3. 4) control electrical excitability in many different
cells. Among their functions relevant to human physiology and disease, they regulate the …

Inward rectifier K+ channels, which modulate electrical activity in many cell types, are
regulated by protein kinases,, guanine-nucleotide-binding proteins (G proteins),,, and …

To study the role of G protein-coupled, inwardly rectifying K+(GIRK) channels in mediating
neurotransmitter actions in hippocampal neurons, we have examined slices from transgenic …

▪ Abstract Guanine nucleotide binding (G) proteins relay extracellular signals encoded in
light, small molecules, peptides, and proteins to activate or inhibit intracellular enzymes and …

TASK is a new member of the recently recognized TWIK K+ channel family. This 395 amino
acid polypeptide has four transmembrane segments and two P domains. In adult human …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

G protein-gated inwardly rectifying potassium channels (Kir3/GirK) are important for
maintaining resting membrane potential, cell excitability and inhibitory neurotransmission …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …