Nociception is the process whereby primary afferent nerve fibers of the somatosensory
system detect noxious stimuli. Pungent irritants from pepper, mint, and mustard plants have …

Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …

Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation
channel that serves as the primary heat and capsaicin sensor in humans. Using cryo-EM, we …

A key assumption of optogenetics is that light only affects opsin-expressing neurons.
However, illumination invariably heats tissue, and many physiological processes are …

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …

Our ability to perceive temperature is crucial: it enables us to swiftly react to noxiously cold or
hot objects and helps us to maintain a constant body temperature. Sensory nerve endings …

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is
an important drug target to treat epilepsy, pain and several other diseases related to …

Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and
selectivity. Although a capsaicin-bound channel structure was previously resolved by cryo …

Olmsted syndrome (OS) is a rare congenital disorder characterized by palmoplantar and
periorificial keratoderma, alopecia in most cases, and severe itching. The genetic basis for …