Integrins are cell adhesion molecules that mediate cell-cell, cell–extracellular matrix, and
cell-pathogen interactions. They play critical roles for the immune system in leukocyte …

Beyond an eminent role in hemostasis and thrombosis, platelets are characterized by expert
functions in assisting and modulating inflammatory reactions and immune responses. This is …

Regulation of integrin affinity (activation) is essential for metazoan development and for
many pathological processes. Binding of the talin phosphotyrosine-binding (PTB) domain to …

Abstract αβ heterodimeric integrins mediate dynamic adhesive cell-cell and cell-extracellular
matrix (ECM) interactions in metazoa that are critical in growth and development …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …

Platelets are central mediators of thrombosis and hemostasis. At the site of vascular injury,
platelet accumulation (ie adhesion and aggregation) constitutes the first wave of hemostasis …

Integrins are α/β heterodimeric adhesion glycoprotein receptors that regulate a wide variety
of dynamic cellular processes such as cell migration, phagocytosis, and growth and …

Integrin signaling is bidirectional.'Inside-out'signals regulate integrin affinity for adhesive
ligands, and ligand-dependent 'outside-in'signals regulate cellular responses to adhesion …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …