The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

Cells utilize diverse ATP-dependent nucleosome-remodelling complexes to carry out
histone sliding, ejection or the incorporation of histone variants, suggesting that different …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Eight types of short-chain Lys acylations have recently been identified on histones:
propionylation, butyrylation, 2-hydroxyisobutyrylation, succinylation, malonylation …

Upon stimulation, small numbers of naive CD8+ T cells proliferate and differentiate into a
variety of memory and effector cell types. CD8+ T cells can persist for years and kill tumour …

Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine
acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in …