Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies

DR Skvarc, M Berk, LK Byrne, OM Dean, S Dodd… - Neuroscience & …, 2018 - Elsevier
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Pregabalin affords retinal neuroprotection in diabetic rats: Suppression of retinal glutamate, microglia cell expression and apoptotic cell death

SA Ali, SA Zaitone, AA Dessouki, AA Ali - Experimental eye research, 2019 - Elsevier
Pregabalin is the first drug to receive FDA approval for treating diabetic neuropathic pain.
This study investigated the neuroprotective effect of pregabalin in an experimental model of …

Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury

MS Meymandi, Z Soltani, G Sepehri, S Amiresmaili… - Brain research …, 2018 - Elsevier
Brain edema and increased intracranial pressure (ICP) are among the main causes of
neurological disturbance and mortality following traumatic brain injury (TBI). Since …

Neuroprotective methodologies of Co-enzyme Q10 mediated brain hemorrhagic treatment: clinical and pre-clinical findings

K Rajdev, S Mehan - CNS & Neurological Disorders-Drug …, 2019 - benthamdirect.com
Cerebral brain hemorrhage is associated with the highest mortality and morbidity despite
only constituting approximately 10-15% of all strokes classified into intracerebral and …

Effect of pregabalin on contextual memory deficits and inflammatory state-related protein expression in streptozotocin-induced diabetic mice

K Sałat, J Gdula-Argasińska, N Malikowska… - Naunyn-Schmiedeberg's …, 2016 - Springer
Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to defects in
insulin secretion or its action. Complications from long-term diabetes consist of numerous …

Mitochondrial‐Protective Effects of R‐Phenibut after Experimental Traumatic Brain Injury

E Kupats, G Stelfa, B Zvejniece… - Oxidative Medicine …, 2020 - Wiley Online Library
Altered neuronal Ca2+ homeostasis and mitochondrial dysfunction play a central role in the
pathogenesis of traumatic brain injury (TBI). R‐Phenibut ((3R)‐phenyl‐4‐aminobutyric acid) …

[HTML][HTML] Role of gabapentin in traumatic brain injury: A prospective comparative study

R Singh, S Ambasta, PS Bais, A Azim… - Indian journal of …, 2024 - ncbi.nlm.nih.gov
Background Traumatic brain injury (TBI) is a major cause of mortality among young
individuals, accounting for 65% of deaths in road traffic accidents. Paroxysmal sympathetic …

The protective effect of omeprazole against traumatic brain injury: an experimental study

R Özay, ME Türkoğlu, B Gürer, H Dolgun, O Evirgen… - World Neurosurgery, 2017 - Elsevier
Background The development of secondary brain injury via oxidative stress after traumatic
brain injury (TBI) is a well-known entity. Consequently, the aim of the present study was to …

Levetiracetam, an antiepileptic drug has neuroprotective effects on intracranial hemorrhage injury

T Imai, T Sugiyama, S Iwata, S Nakamura… - Neuroscience, 2020 - Elsevier
Intracranial hemorrhage (ICH) is a devastating disease that induces hematoma formation
with poor neuronal outcome. Levetiracetam (LEV) has been approval for epilepsy seizures …

[PDF][PDF] Red fruit (Pandanus conoideus Lam) oil ameliorates streptozotocin-induced diabetic peripheral neuropathy by targeting the oxidative and inflammatory …

IT Lestari, K Anggadiredja, AN Garmana - Pharmacia, 2024 - pharmacia.pensoft.net
Diabetic peripheral neuropathy (DPN) is a common comorbid in diabetic patients. Oxidative
stress and inflammation are key to DPN's etiology, making them possible therapy targets …