Summary T helper type 17 (Th17) and regulatory T (Treg) cells are active players in the
establishment of tolerance and defence. These attributes of the immune system enmesh to …

The biomolecules inside or near cells form a complex interacting system. Cellular
phenotypes and behaviors arise from the totality of interactions among the components of …

Given the complexity and interactive nature of biological systems, constructing informative
and coherent network models of these systems and subsequently developing efficient …

Computational modeling constitutes a crucial step toward the functional understanding of
complex cellular networks. In particular, logical modeling has proven suitable for the …

Aging is a biological process characterized by the progressive functional decline of many
interrelated physiological systems. In particular, aging is associated with the development of …

CD4+ T cells orchestrate the adaptive immune response in vertebrates. While both
experimental and modeling work has been conducted to understand the molecular genetic …

Terminal differentiation of B cells is an essential process for the humoral immune response
in vertebrates and is achieved by the concerted action of several transcription factors in …

The dynamical analysis of large biological regulatory networks requires the development of
scalable methods for mathematical modeling. Following the approach initially introduced by …

It is coming nowadays more clear that in order to obtain a unified description of the different
mechanisms governing the behavior and causality relations among the various parts of a …

One of the greatest challenges in biomedicine is to get a unified view of observations made
from the molecular up to the organism scale. Towards this goal, multiscale models have …