It has been 50years since Gross and Lapiere discovered collagenolytic activity during
tadpole tail metamorphosis, which was later on revealed as MMP-1, the founding member of …

Damage to the central nervous system (CNS) is one of the leading causes of morbidity and
mortality in elderly, as repair after lesions or neurodegenerative disease usually fails …

Intense light exposure causes photoreceptor apoptosis in dark-adapted adult albino
zebrafish (Danio rerio). Subsequently, Müller glia increase expression of the Achaete-scute …

The regenerative failure of mammalian optic axons is partly mediated by Socs3-dependent
inhibition of Jak/Stat signaling (, 2011). Whether Jak/Stat signaling is part of the normal …

Zebrafish have the remarkable capacity to regenerate retinal neurons following a variety of
damage paradigms. Following initial tissue insult and a period of cell death, a proliferative …

Highlights•CNS axons of adult zebrafish regenerate successfully.•Neurons with
regenerating axons switch on regeneration-associated genes.•There is little evidence for …

Neurodegenerative retinal diseases, such as glaucoma and diabetic retinopathy, involve a
gradual loss of neurons in the retina as the disease progresses. Central nervous system …

Background: Traumatic optic nerve injury is a leading cause of irreversible blindness across
the world and causes progressive visual impairment attributed to the dysfunction and death …

As the mammalian central nervous system matures, its regenerative ability decreases,
leading to incomplete or non‐recovery from the neurodegenerative diseases and central …

Traumatic brain injury and spinal cord injury are devastating conditions that may result in
death or long-term disability. A promising strategy for the development of effective cell …