Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal
homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress …

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the
epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types …

Melanoma is a lethal melanocytic neoplasm. Unfortunately, the histological diagnosis can
be difficult at times. Distinguishing ambiguous melanocytic neoplasms that are benign nevi …

The tumor microenvironment is shaped by interactions between malignant cells and host
cells representing an integral component of solid tumors. Host cells, including elements of …

Skin malignant melanoma (MM) is an aggressive cancer with an increasing incidence with
limited therapies in advanced stages. Tumor-associated macrophages (TAMs) are the major …

The role of tumor-associated macrophages (TAMs) in cutaneous melanoma is controversial.
TAMs include immunogenic and immunosuppressive subtypes, and have distinct functions …

Metallothioneins (MTs) are small cysteine-rich intracellular proteins with four major isoforms
identified in mammals, designated MT-1 through MT-4. The best known biological functions …

Gray zone lymphoma (GZL), a B-cell lymphoma with features intermediate between large B-
cell lymphoma (LBCL) and classic Hodgkin lymphoma (cHL), is a rare and poorly defined …

Earlier identification of aggressive melanoma remains a goal in the field of melanoma
research. With new targeted and immune therapies that have revolutionized the care of …

Metallothioneins (MTs) are low molecular weight proteins, which are present in almost all
types of organisms. In mammals, four main MT isoforms designated from MT-1 to MT-4 were …