Latency and tumorigenesis in Marek's disease

V Nair - Avian diseases, 2013 - meridian.allenpress.com
Despite the remarkable progress in our understanding of Marek's disease (MD) and the
causative Marek's disease virus (MDV) biology, a number of major features of this complex …

Viral factors involved in Marek's disease virus (MDV) pathogenesis

LD Bertzbach, A Kheimar, FAZ Ali… - Current Clinical …, 2018 - Springer
Abstract Purpose of Review Marek's disease virus (MDV) is a highly oncogenic
alphaherpesvirus that causes various clinical symptoms including fatal lymphomas in …

Critical role of the virus-encoded microRNA-155 ortholog in the induction of Marek's disease lymphomas

Y Zhao, H Xu, Y Yao, LP Smith, L Kgosana… - PLoS …, 2011 - journals.plos.org
Notwithstanding the well-characterised roles of a number of oncogenes in neoplastic
transformation, microRNAs (miRNAs) are increasingly implicated in several human cancers …

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion

K Li, Y Liu, Z Xu, Y Zhang, D Luo, Y Gao, Y Qian… - PLoS …, 2019 - journals.plos.org
The cellular DNA sensor cGMP-AMP synthase (cGAS) detects cytosolic viral DNA via the
stimulator of interferon genes (STING) to initiate innate antiviral response. Herpesviruses are …

[HTML][HTML] Characterizaton of gamma delta T cells in Marek's disease virus (Gallid herpesvirus 2) infection of chickens

AMS Laursen, RR Kulkarni, K Taha-Abdelaziz… - Virology, 2018 - Elsevier
Immunity against Marek's disease (MD), caused by Gallid herpesvirus 2 (GaHV-2), in
chickens is mediated by both innate and adaptive responses. The present study evaluated …

The Meq oncoprotein of Marek's disease virus interacts with p53 and inhibits its transcriptional and apoptotic activities

X Deng, X Li, Y Shen, Y Qiu, Z Shi, D Shao, Y Jin… - Virology journal, 2010 - Springer
Background Marek's disease virus (MDV) is an oncogenic herpesvirus, which causes
malignant lymphoma in chickens. The Meq protein of MDV, which is expressed abundantly …

[HTML][HTML] An important role of the heat shock response in infected cells for replication of baculoviruses

YV Lyupina, SB Dmitrieva, AV Timokhova… - Virology, 2010 - Elsevier
Baculoviruses serve as a stress factor that can activate both death-inducing and
cytoprotective pathways in infected cells. In this report, induction of heat shock proteins …

Functional analysis of Hikeshi reveals physiological significance of nuclear Hsp70

N Imamoto - Current Opinion in Cell Biology, 2024 - Elsevier
Nucleocytoplasmic transport is a basic cellular reaction that plays an important role in
regulating cell physiology in eukaryotic cells. Here we show that the identification of one …

Marek's disease virus activates the PI3K/akt pathway through interaction of its protein meq with the P85 subunit of PI3K to promote viral replication

H Li, J Zhu, M He, Q Luo, F Liu, R Chen - Frontiers in Microbiology, 2018 - frontiersin.org
It is known that viruses can active the phosphatidylinositol 3-kinase (PI3K)/Akt signaling
pathway in host cells to support cell survival and viral replication; however, the role of …

Transcriptome and proteome profiling of host responses to Marek's disease virus in chickens

K Haq, JT Brisbin, N Thanthrige-Don, M Heidari… - Veterinary immunology …, 2010 - Elsevier
Marek's disease (MD) is an immunosuppressive and proliferative disease of domestic
chickens caused by a highly oncogenic cell-associated alpha-herpesvirus, named Marek's …