Background and Objectives: The US Food and Drug Administration (FDA) defines a
biomarker as a characteristic that is measured as an indicator of normal biological …

Neurodegenerative diseases constitute a broad range of central nervous system disorders,
characterized by neuronal degeneration. Alzheimer's disease, Parkinson's disease …

Abstract Background Clinical trials in Alzheimer's disease (AD) had high failure rates for
several reasons, including the lack of biological endpoints. Fluid-based biomarkers may …

Vascular cognitive impairment (VCI), encompassing vascular dementia, has been claimed
as the “second-most common dementia” after Alzheimer Disease. Whether or not this is true …

INTRODUCTION We investigated the association of inflammatory mechanisms with markers
of Alzheimer's disease (AD) pathology and rates of cognitive decline in the AD spectrum …

Cerebrovascular damage coexists with Alzheimer's disease (AD) pathology and increases
AD risk. However, it is unclear whether endothelial progenitor cells reduce AD risk via …

Purpose This paper aims to evaluate the effect of consumption of a high-fat diet (HFD) rich
with total saturated fats on adiposity and serum levels of vascular cell adhesion molecule …

Several studies have shown that metabolic disorders such as type-2 diabetes (T2DM) play a
role in propagating neurodegenerative disorders like Alzheimer's Disease (AD)(1). As the …

Neurological diseases with a neurodegenerative component have been associated with
alterations in the cerebrovasculature. At the anatomical level, these are centred around …

Brain health means optimal physiological brain function across the normal life-course. It
encompasses not only healthy brain aging but also brain diseases, their diagnosis and …