An appraisal of natural products active against parasitic nematodes of animals
Here, the scientific and patent literature on the activities of purified natural compounds has
been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery …
been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery …
An enumeration of natural products from microbial, marine and terrestrial sources
F Ntie-Kang, D Svozil - Physical Sciences Reviews, 2020 - degruyter.com
The discovery of a new drug is a multidisciplinary and very costly task. One of the major
steps is the identification of a lead compound, ie a compound with a certain degree of …
steps is the identification of a lead compound, ie a compound with a certain degree of …
Natural Algaecide Sphingosines Identified in Hybrid Straw Decomposition Driven by White‐Rot Fungi
Harmful algal blooms (HABs), which are promoted by eutrophication and intensified by
global warming, occur worldwide. Allelochemicals, which are natural chemicals derived from …
global warming, occur worldwide. Allelochemicals, which are natural chemicals derived from …
Enhancing the discovery of bioactive secondary metabolites from fungal endophytes using chemical elicitation and variation of fermentation media
MM Gakuubi, KC Ching, M Munusamy… - Frontiers in …, 2022 - frontiersin.org
Endophytic microorganisms are an important source of bioactive secondary metabolites. In
this study, fungal endophytes obtained from A* STAR's Natural Product Library (NPL) and …
this study, fungal endophytes obtained from A* STAR's Natural Product Library (NPL) and …
In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation
KRV Thappeta, LN Zhao, CE Nge, S Crasta… - International Journal of …, 2020 - mdpi.com
Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins
to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA …
to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA …
Exploring a general multi-pronged activation strategy for natural product discovery in Actinomycetes
Natural products possess significant therapeutic potential but remain underutilized despite
advances in genomics and bioinformatics. While there are approaches to activate and …
advances in genomics and bioinformatics. While there are approaches to activate and …
New high-throughput screening identifies compounds that reduce viability specifically in liver cancer cells that express high levels of SALL4 by inhibiting oxidative …
Background & Aims Some oncogenes encode transcription factors, but few drugs have been
successfully developed to block their activity specifically in cancer cells. The transcription …
successfully developed to block their activity specifically in cancer cells. The transcription …
Tandem mass spectral metabolic profiling of 54 actinobacterial strains and their 459 mutants
Natural products encompass a diverse range of compounds with high impact applications in
consumer care, agriculture and most notably, therapeutics. However, despite the expansive …
consumer care, agriculture and most notably, therapeutics. However, despite the expansive …
Expression and engineering of PET-degrading enzymes from Microbispora, Nonomuraea, and Micromonospora
Low recycling rates coupled with increased production have resulted in an alarming rapid
accumulation of a widely used plastic material, polyethylene terephthalate (PET). With the …
accumulation of a widely used plastic material, polyethylene terephthalate (PET). With the …
Antibacterial Spirotetronate Polyketides from an Actinomadura sp. Strain A30804
Large scale cultivation and chemical investigation of an extract obtained from Actimonadura
sp. resulted in the identification of six previously undescribed spirotetronates (pyrrolosporin …
sp. resulted in the identification of six previously undescribed spirotetronates (pyrrolosporin …