Candidate gene–environment interaction research: Reflections and recommendations
Studying how genetic predispositions come together with environmental factors to contribute
to complex behavioral outcomes has great potential for advancing the understanding of the …
to complex behavioral outcomes has great potential for advancing the understanding of the …
Alcohol biomarkers in applied settings: recent advances and future research opportunities
RZ Litten, AM Bradley, HB Moss - Alcoholism: Clinical and …, 2010 - Wiley Online Library
During the past decade, advances have been made in the identification, development, and
application of alcohol biomarkers. This is important because of the unique functions that …
application of alcohol biomarkers. This is important because of the unique functions that …
A population-specific HTR2B stop codon predisposes to severe impulsivity
Impulsivity, describing action without foresight, is an important feature of several psychiatric
diseases, suicidality and violent behaviour. The complex origins of impulsivity hinder …
diseases, suicidality and violent behaviour. The complex origins of impulsivity hinder …
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption
Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is
largely unknown, despite its clinical and societal importance. We report a genome-wide …
largely unknown, despite its clinical and societal importance. We report a genome-wide …
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide
Childhood trauma is associated with hypothalamic–pituitary–adrenal (HPA) axis
dysregulation and is a known risk factor for suicidal behavior. In this study we sought to …
dysregulation and is a known risk factor for suicidal behavior. In this study we sought to …
Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia
TA Greenwood, LC Lazzeroni… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: The authors used a custom array of 1,536 single-nucleotide polymorphisms
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …
(SNPs) to interrogate 94 functionally relevant candidate genes for schizophrenia and identify …
Chronic cigarette smoking: implications for neurocognition and brain neurobiology
Compared to the substantial volume of research on the general health consequences
associated with chronic smoking, little research has been specifically devoted to the …
associated with chronic smoking, little research has been specifically devoted to the …
Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures
Mu-opioid receptors (MOPRs) are critically involved in the modulation of pain and analgesia,
and represent a candidate mechanism for the development of biomarkers of pain conditions …
and represent a candidate mechanism for the development of biomarkers of pain conditions …
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior
A Roy, CA Hodgkinson, V DeLuca, D Goldman… - Journal of psychiatric …, 2012 - Elsevier
Childhood trauma is associated with hypothalamic–pituitary–adrenal (HPA) axis
dysregulation. Both factors increase risk for suicidal behavior. Corticotropin releasing …
dysregulation. Both factors increase risk for suicidal behavior. Corticotropin releasing …
Interaction between FKBP5 and childhood trauma and risk of aggressive behavior
L Bevilacqua, V Carli, M Sarchiapone… - Archives of general …, 2012 - jamanetwork.com
Context Childhood trauma may predispose individuals to aggressive behavior, and both
childhood trauma and aggressive behavior are associated with hypothalamic-pituitary …
childhood trauma and aggressive behavior are associated with hypothalamic-pituitary …