Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

Atherosclerosis is the onset of endothelial cell damage and is characterized by abnormal
accumulation of fibrinogen and lipid in large and middle arteries. Recent researches …

Gender difference is well recognized as a key risk factor for cardiovascular disease (CVD).
Estrogen, the primary female sex hormone, improves cardiovascular functions through …

Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+
influx in non-excitable and excitable (ie, skeletal and cardiac muscle) cells. These channels …

Calcium is an important second messenger required not only for the excitation-contraction
coupling of the heart but also critical for the activation of cell signaling pathways involved in …

Purpose: The molecular etiology of atrial fibrillation (AF) and its treatment are poorly
understood. AF involves both electrical and structural features. Vericiguat can ameliorate …

Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-
economic burden. Calcium (Ca2+) dysregulation is key hallmark of the failing myocardium …

Heart failure with preserved ejection fraction (HFpEF) is an essential subtype of heart failure
accounting for 40% of the total. However, the related pathological mechanism and drug …

Metabolic syndrome (MS) is a complex pathology characterized by visceral adiposity, insulin
resistance, arterial hypertension, and dyslipidaemia. It has become a global epidemic …

Transient receptor potential canonical (TRPC) channels are ubiquitously expressed in
excitable and non-excitable cardiac cells where they sense and respond to a wide variety of …