Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …

Cyclic nucleotide phosphodiesterase 4 (PDE4) specifically hydrolyzes cyclic adenosine
monophosphate (cAMP) and plays vital roles in biological processes such as cancer …

Phosphodiesterases (PDEs) are a class of enzymes that hydrolyze cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) which is involved in …

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease
(CD), is a class of severe and chronic diseases of the gastrointestinal (GI) tract with recurrent …

Cyclic nucleotide phosphodiesterases 4 (PDE4) are a family of enzymes which specifically
promote the hydrolysis and degradation of cAMP. The inhibition of PDE4 enzymes has been …

The histidine–aspartate (HD)-domain protein superfamily contains metalloproteins that
share common structural features but catalyze vastly different reactions ranging from …

Aim: To evaluate the impact of pentoxifylline on blood pressure (BP) and plasma TNF-α, C-
reactive protein (CRP) and IL-6 through a systematic review and meta-analysis of …

Purpose: Lung cancer remains the leading cause of cancer-related deaths worldwide and
novel therapeutic approaches targeting crucial pathways are urgently needed to improve its …

Sildenafil is the first phosphodiesterase-5 inhibitor used for the treatment of erectile
dysfunction. However, recent studies have been suggesting an antitumor effect of sildenafil …

Phosphodiesterase 7 (PDE7) is an intracellular enzyme that specifically hydrolyzes the
second messenger, cyclic-3', 5'-adenosine monophosphate (cAMP), into inactive noncyclic …