Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician

EY Podyacheva, EA Kushnareva, AA Karpov… - Frontiers in …, 2021 - frontiersin.org
Today the pharmacological possibilities of treating cancer are expanding and as a result, life
expectancy is increasing against the background of chemotherapy and supportive treatment …

[HTML][HTML] Research progress of active ingredients of Scutellaria baicalensis in the treatment of type 2 diabetes and its complications

W Yingrui, L Zheng, L Guoyan, W Hongjie - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term
hyperglycemia can lead to a variety of serious chronic complications, such as diabetic …

Targeting OCT3 attenuates doxorubicin-induced cardiac injury

KM Huang, M Zavorka Thomas… - Proceedings of the …, 2021 - National Acad Sciences
Doxorubicin is a commonly used anticancer agent that can cause debilitating and
irreversible cardiac injury. The initiating mechanisms contributing to this side effect remain …

S100A8/A9 in myocardial infarction: a promising biomarker and therapeutic target

ZL Cai, Q Xie, T Hu, Q Yao, J Zhao, Q Wu… - Frontiers in cell and …, 2020 - frontiersin.org
Myocardial infarction (MI), the main cause of cardiovascular-related deaths worldwide, has
long been a hot topic because of its threat to public health. S100A8/A9 has recently attracted …

Pathogenic roles of neutrophil‐derived alarmins (S100A8/A9) in heart failure: From molecular mechanisms to therapeutic insights

B Bai, Y Xu, H Chen - British Journal of Pharmacology, 2023 - Wiley Online Library
An excessive neutrophil count is recognized as a valuable predictor of inflammation and is
associated with a higher risk of adverse cardiac events in patients with heart failure. Our …

Redox imbalances in ageing and metabolic alterations: implications in cancer and cardiac diseases. An overview from the working group of cardiotoxicity and …

V Mercurio, A Cuomo, C Cadeddu Dessalvi, M Deidda… - Antioxidants, 2020 - mdpi.com
Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases.
In addition, several studies indicate that MetS correlates with the increased risk of cancer in …

Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils

H Zhu, M He, YL Wang, Y Zhang, J Dong… - Bioengineering & …, 2023 - Wiley Online Library
Doxorubicin (DOX)‐induced cardiotoxicity limits its broad use as a chemotherapy agent. The
development of effective and non‐invasive strategies to prevent DOX‐associated adverse …

Identifying the transcriptome signatures of calcium channel blockers in human induced pluripotent stem cell–derived cardiomyocytes

CK Lam, L Tian, N Belbachir, A Wnorowski… - Circulation …, 2019 - Am Heart Assoc
Rationale: Calcium channel blockers (CCBs) are an important class of drugs in managing
cardiovascular diseases. Patients usually rely on these medications for the remainder of …

Exploring novel biomarkers in dilated cardiomyopathy‑induced heart failure by integrated analysis and in vitro experiments

L Zhou, F Peng, J Li, H Gong - Experimental and …, 2023 - spandidos-publications.com
Despite the availability of several effective and promising treatment methods, heart failure
(HF) remains a significant public health concern that requires advanced therapeutic …

[HTML][HTML] Doxorubicin-induced cardiotoxicity and risk factors

C Belger, C Abrahams, A Imamdin, S Lecour - IJC Heart & Vasculature, 2024 - Elsevier
Doxorubicin (DOX) is an anthracycline antibiotic widely used as a chemotherapeutic agent
to treat solid tumours and hematologic malignancies. Although useful in the treatment of …