Animal studies have been instrumental in providing evidence for exercise-induced
neuroplasticity of corticostriatal circuits that are profoundly affected in Parkinson's disease …

Molecular imaging with PET offers a broad variety of tools supporting the diagnosis of
movement disorders. The more widely applied PET imaging techniques have focused on the …

Objective To assess reductions of cerebral glucose metabolism in Parkinson's disease (PD)
with 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET), and their …

Abstract Rationale In Parkinson's disease (PD), spatial covariance analysis of 18 F-FDG
PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By …

To explore the effects of PD pathology on brain connectivity, we characterized with an
emergent computational approach the brain metabolic connectome using [18F] FDG-PET in …

Aim: We sought to identify markers of motor and nonmotor function in Parkinson's disease
(PD) using advanced neuroimaging techniques in subjects with PD. Methods: We enrolled …

Parkinson's disease (PD) is associated with distinct metabolic covariance patterns that relate
to the motor and cognitive manifestations of the disorder. It is not known, however, how the …

Purpose Neuroimaging indicators of Parkinson disease have been developed and applied
in clinical practices. Dopaminergic imaging reflects nigrostriatal dopaminergic dysfunction …

Damage to nonmotor dopamine (DA)-mediated frontostriatal circuits has been proposed as
the main pathophysiological basis of cognitive dysfunction in Parkinson's disease (PD). In …

Objective: To characterize brain metabolic changes associated with mild cognitive
impairment (MCI) in drug-naive patients with Parkinson disease (PD) using 18F …