Multidrug resistance (MDR) is the dominant challenge in the failure of chemotherapy in
cancers. Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that spreads intracellular …

While cisplatin and carboplatin are active versus most common cancers, epithelial
malignancies are incurable when metastatic. Even if an initial response occurs, acquired …

Activation of transcription factor NF-κB is frequently encountered in tumor cells and
contributes to aggressive tumor growth and resistance to chemotherapy and ionizing …

The resistance of many types of cancer to conventional chemotherapies is a major factor
undermining successful cancer treatment. In this review, the role of a signal transduction …

Gynecological cancers are known for being very aggressive at their advanced stages.
Indeed, the survival rate of both ovarian and endometrial cancers is very low when …

Simple Summary When tumors become resistant to chemotherapeutics, alternative
treatment strategies must be explored. Gene targeting provides a personalized and …

Apoptosis, or programmed cell death, has an essential role in controlling cell number in
many developmental and physiological settings and in chemotherapy-induced tumour-cell …

The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

The X-linked inhibitor of apoptosis (XIAP) is a promising new molecular target for the design
of novel anticancer drugs aiming at overcoming apoptosis-resistance of cancer cells to …

Akt negatively regulates apoptotic pathways at a premitochondrial level through
phosphorylation and modulation of proteins such as Bad, Forkhead proteins, and GSK-3β …