Development of fluorescent peptide G protein‐coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators
G protein‐coupled receptors (GPCRs) are widely therapeutically targeted, and recent
advances in allosteric modulator development at these receptors offer further potential for …
advances in allosteric modulator development at these receptors offer further potential for …
Design, synthesis, and application of fluorescent ligands targeting the intracellular allosteric binding site of the CXC chemokine receptor 2
BM Casella, JP Farmer, DN Nesheva… - Journal of Medicinal …, 2023 - ACS Publications
The inhibition of CXC chemokine receptor 2 (CXCR2), a key inflammatory mediator, is a
potential strategy in the treatment of several pulmonary diseases and cancers. The …
potential strategy in the treatment of several pulmonary diseases and cancers. The …