Tumor immunotherapy is only effective in a fraction of patients due to a low response rate
and severe side effects, and these challenges of immunotherapy in clinics can be addressed …

Although it was thought that apoptotic cells, when rapidly phagocytosed, underwent a silent
death that did not trigger an immune response, in recent years a new concept of …

Background Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many
myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative …

Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …

Despite advances in treatments like chemotherapy and radiotherapy, metastatic cancer
remains a leading cause of death for cancer patients. While many chemotherapeutic agents …

Calreticulin (CALR) mutations were recently described in JAK2 and MPL unmutated primary
myelofibrosis (PMF) and essential thrombocythemia. In the current study, we compared the …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …

Recurrent somatic mutations of calreticulin (CALR) have been identified in patients
harboring myeloproliferative neoplasms; however, their role in tumorigenesis remains …

The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque.
Although apoptotic cells are cleared quickly in almost all other tissue beds, their removal …

Radiation therapy (RT) is used for local tumor control through direct killing of tumor cells.
Radiation-induced cell death can trigger tumor antigen-specific immune responses, but …