In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye

K Peynshaert, J Devoldere, SC De Smedt… - Advanced drug delivery …, 2018 - Elsevier
Many ocular disorders leading to blindness could benefit from efficient delivery of
therapeutics to the retina. However, despite extensive research into drug delivery vehicles …

Fine membrane forceps with integral scraping feature

G Vezzu - US Patent 10,039,565, 2018 - Google Patents
Membrane forceps for performing an ILM or ERM peel procedure include a handle, a tube
extending from the handle, and forceps jaws extending from the tube. The forceps jaws may …

Surgical instrument with adhesion optimized edge condition

G Vezzu, R Grueebler - US Patent 10,973,682, 2021 - Google Patents
A surgical instrument such as for use in vitreoretinal sur geries is described. The surgical
instrument may include a pair of pincers resiliently biased toward an opened configu ration …

[HTML][HTML] A review of last decade developments on epiretinal membrane pathogenesis

E Tsotridou, E Loukovitis, K Zapsalis… - … and Innovation in …, 2020 - ncbi.nlm.nih.gov
Epiretinal membrane (ERM) is a pathologic tissue that develops at the vitreoretinal interface.
ERM is responsible for pathological changes of vision with varying degrees of clinical …

[HTML][HTML] TLR2 and TLR4 Are Expressed in Epiretinal Membranes: Possible Links with Vitreous Levels of Complement Fragments and DAMP-Related Proteins

L Dinice, G Esposito, A Cacciamani… - International Journal of …, 2024 - mdpi.com
Previous studies reported the expression of toll-like receptors (TLRs), merely TLR2 and
TLR4, and complement fragments (C3a, C5b9) in vitreoretinal disorders. Other than …

[HTML][HTML] Efficacy and safety of vitrectomy with internal limiting membrane peeling for diabetic macular edema: a Meta-analysis

XY Hu, H Liu, LN Wang, YZ Ding… - International Journal of …, 2018 - ncbi.nlm.nih.gov
Abstract● AIM: To evaluate the efficacy and safety of vitrectomy with internal limiting
membrane (ILM) peeling for diabetic macular edema (DME).● METHODS: The PubMed …

Intraretinal changes in idiopathic versus diabetic epiretinal membranes after macular peeling

MR Romano, G Ilardi, M Ferrara, G Cennamo… - PLoS …, 2018 - journals.plos.org
Introduction Epiretinal traction is not responsible only for epiretinal but also intraretinal
changes. This study aims to describe structural and vascular intraretinal changes after …

A surgical simulator for peeling the inner limiting membrane during wet conditions

S Omata, Y Someya, S Adachi, T Masuda… - PloS one, 2018 - journals.plos.org
The present study was performed to establish a novel ocular surgery simulator for training in
peeling of the inner limited membrane (ILM). This simulator included a next-generation …

A thin-film optogenetic visual prosthesis

EB Knudsen, K Zappitelli, J Brown, J Reeder, KS Smith… - bioRxiv, 2023 - biorxiv.org
Retinitis pigmentosa and macular degeneration lead to photoreceptor death and loss of
visual perception. Despite recent progress, restorative technologies for photoreceptor …

Internal limiting membrane disruption facilitates engraftment of transplanted human stem cell derived retinal ganglion cells

EA Aguzzi, KY Zhang, A Nagalingam, S Quillen… - bioRxiv, 2022 - biorxiv.org
Retinal ganglion cell (RGC) death causes irreversible vision loss in patients with glaucoma
and other forms of optic neuropathy because the mammalian retina and optic nerve lack …