Urothelial carcinoma is a common malignancy that carries a poor prognosis when the
disease includes muscle invasion. Metastatic urothelial carcinoma is almost uniformly fatal …

This 2004 volume in the World Health Organization series on histologic and genetic typing
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

Bladder cancer is the 9th most prevalent cancer worldwide and carries a protracted
treatment course with significant patient expense, morbidity, and mortality. Over 95% of …

In vitro experiments have demonstrated that epidermal growth factor (EGF)-related peptides
activate distinct subsets of ErbB receptors and differ in their biological activities. The …

Previously we reported that when cells from the human transitional cell carcinoma cell line
253J BV growing orthotopically within the bladder of athymic nude mice were treated with …

Purpose: Expression of various members of the ErbB family (epidermal growth factor
receptor/ErbB-1, ErbB-2, ErbB-3 and ErbB-4) is associated with disease stage and survival …

Members of the epidermal growth factor (EGF) family have been suggested as prognostic
markers in patients with bladder cancer. Thus far, there has been no consensus on their …

Epidermal growth factor receptor (EGFR) is an effective target for those patients with
metastatic colorectal cancers that retain the wild-type RAS gene. However, its efficacy in …

In the majority of cases, death from bladder cancer results from metastatic disease.
Understanding the closely linked mechanisms of invasion, metastasis and angiogenesis in …

Purpose: The purpose of this research was to quantitatively analyze tumor-specific
overexpression of all ErbB receptors and ErbB4 isoforms in transitional cell carcinoma …