Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Extensive experimental evidence shows that platelets support tumour metastasis. The
activation of platelets and the coagulation system have a crucial role in the progression of …

The barrier properties of endothelial cells are critical for the maintenance of water and
protein balance between the intravascular and extravascular compartments. An impairment …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Platelets are chief effector cells in hemostasis. In addition, however, their specializations
include activities and intercellular interactions that make them key effectors in inflammation …

The kidney is comprised of heterogeneous cell populations that function together to perform
a number of tightly controlled, complex and interdependent processes. Renal endothelial …

Abstract Sphingosine 1-phosphate (S1P), which acts via G protein-coupled S1P receptors
(S1PRs), is a bioactive lipid essential for vascular integrity and lymphocyte trafficking. The …

Inflammation is an underlying feature of a variety of human diseases. An important
manifestation of this pathophysiological response is microvascular dysfunction, which …

Our prior in vitro studies indicate that sphingosine 1-phosphate (S1P), a phospholipid
angiogenic factor, produces endothelial cell barrier enhancement through ligation of …

The novel immunomodulator FTY720 is effective in experimental models of transplantation
and autoimmunity, and is currently undergoing Phase III clinical trials for prevention of …