Planar polarity describes the coordinated polarization of cells within the plane of a tissue.
This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar …

Cell polarity is a fundamental property used to generate asymmetry and structure in all cells.
Cancer is associated with loss of cell and tissue structure. While observations made in …

Leber's hereditary optic neuropathy (LHON) is a maternally inherited eye disease. X-linked
nuclear modifiers were proposed to modify the phenotypic manifestation of LHON …

Epilepsy is a common disabling disease with complex, multifactorial genetic and
environmental etiology. The small fraction of epilepsies subject to Mendelian inheritance …

Core planar cell polarity (PCP) genes, which are involved in various neurodevelopmental
disorders such as neural tube closure, epilepsy, and autism spectrum disorder, have poorly …

Previous work in our laboratory has shown that mutations in prickle (pk) cause myoclonic-
like seizures and ataxia in Drosophila, similar to what is observed in humans carrying …

Introduction Chemoresistance constitutes a prevalent factor that significantly impacts
thesurvival of patients undergoing treatment for smal-cell lung cancer (SCLC) …

Defects in neuronal migration cause brain malformations, which are associated with
intellectual disability (ID) and epilepsy. Using exome sequencing, we identified compound …

Drosophila dorsal air sac development depends on Decapentaplegic (Dpp) and Fibroblast
growth factor (FGF) proteins produced by the wing imaginal disc and transported by …

Epilepsy is one of the most common neurologic disorders. Around one third of patients do
not respond to current medications. This lack of treatment indicates a need for better …