Systemic autoimmune diseases are characterized by the failure of the immune system to
differentiate self from non-self. These conditions are associated with significant morbidity …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …

The risk and severity of specific infections are increased during pregnancy due to a
combination of physiological and immunological changes. Characterizing the maternal …

Although intermittent increases in inflammation are critical for survival during physical injury
and infection, recent research has revealed that certain social, environmental and lifestyle …

At the frontline of the host defence response, neutrophil antimicrobial functions have
adapted to combat infections and injuries of different origins and magnitude. The release of …

Neutrophil extracellular trap (NET) formation, first described in 2004 as a previously
unknown strategy of neutrophils to fight microbes, has attracted an increasing interest in the …

Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …

Sex hormones are key determinants of gender-related differences and regulate growth and
development during puberty. They also exert a broad range modulation of immune cell …

The contribution of host genetic and nongenetic factors to immunological differences in
humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral …