DNA methylation is a highly regulated process that has a critical role in human development
and homeostatic control of the cell. The number of genes affected by anomalous DNA …

Cancer cells undergo many different alterations during their transformation, including
genetic and epigenetic events. The controlled division of healthy cells can be impaired …

Obesity is associated with increased risk of several diseases and has become epidemic.
Obesity is highly heritable but the genetic variants identified by genome-wide association …

Oral cancer refers to the malignancies that occur in the oral cavity, lip and pharynx with 90%
of oral cancers being squamous cell carcinomas (OSCC). OSCC has the highest mortality …

Aberrant protein phosphorylation is one of the hallmarks of cancer cells, and in many cases
a prerequisite to sustain tumor development and progression. Like protein kinases, protein …

Oral squamous cell carcinomas (OSCC) constitute over 95% of all head and neck
malignancies. As a key component of the tumor microenvironment (TME), chronic …

Oral carcinoma ranks sixth among the most fatal carcinomas, projecting a threat to the entire
world, affecting the head and neck region. It is predominant in men due to several causative …

Abstract Background/Aims: The association between cyclin-dependent kinase inhibitor 2A
(CDKN2A) hypermethylation and head and neck squamous cell carcinoma (HNSCC) risk …

Based on exposure frequency and intrinsic toxicity, lead (Pb) ranks one of the highest
priority toxic materials. Continuous regulation of environmental Pb exposure has contributed …

Background Recent advances in surgery, radiotherapy, and chemotherapy have no
significant effect on oral cancer survival rates due to late diagnosis, poor tumor response to …