The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica

CF Lucchinetti, Y Guo, BFG Popescu… - Brain …, 2014 - Wiley Online Library
Neuromyelitis optica (NMO) is a disabling autoimmune astrocytopathy characterized by
typically severe and recurrent attacks of optic neuritis and longitudinally extensive myelitis …

A review of clinical and imaging findings in tumefactive demyelination

M Nakayama, S Naganawa, M Ouyang… - American Journal of …, 2021 - Am Roentgen Ray Soc
OBJECTIVE. Tumefactive demyelination mimics primary brain neoplasms on imaging, often
necessitating brain biopsy. This article reviews the literature for the clinical and radiologic …

Racial differences in neuromyelitis optica spectrum disorder

SH Kim, MA Mealy, M Levy, F Schmidt, K Ruprecht… - Neurology, 2018 - AAN Enterprises
Objective We aimed to evaluate racial differences in the clinical features of neuromyelitis
optica spectrum disorder. Methods This retrospective review included 603 patients (304 …

Failure of natalizumab to prevent relapses in neuromyelitis optica

I Kleiter, K Hellwig, A Berthele, T Kümpfel… - Archives of …, 2012 - jamanetwork.com
Objective To describe first experiences with the integrin inhibitor natalizumab, given to
patients with suspected relapsing-remitting multiple sclerosis (MS) who were later …

Characteristic brain magnetic resonance imaging abnormalities in central nervous system aquaporin-4 autoimmunity

W Kim, MS Park, SH Lee, SH Kim… - Multiple Sclerosis …, 2010 - journals.sagepub.com
Background: Although neuromyelitis optica has been traditionally regarded as a disease
without brain involvement, brain abnormalities are not uncommon in patients with …

Brain involvement in neuromyelitis optica spectrum disorders

KH Chan, CT Tse, CP Chung, RLC Lee… - Archives of …, 2011 - jamanetwork.com
Background Neuromyelitis optica spectrum disorders (NMOSDs) are severe inflammatory
demyelinating disorders of the central nervous system. Brain involvement is increasingly …

Brain abnormalities in neuromyelitis optica spectrum disorder

W Kim, SH Kim, SY Huh, HJ Kim - Multiple sclerosis …, 2012 - Wiley Online Library
Neuromyelitis optica (NMO) is an idiopathic inflammatory syndrome of the central nervous
system that is characterized by severe attacks of optic neuritis (ON) and myelitis. Until …

Acute disseminated encephalomyelitis: current controversies in diagnosis and outcome

DLH Koelman, FJ Mateen - Journal of neurology, 2015 - Springer
Acute disseminated encephalomyelitis (ADEM) is a rare inflammatory, demyelinating
disorder of the CNS. Only in the past 15 years have larger groups of patients from several …

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

Y Guo, SD Weigand, BF Popescu, VA Lennon… - Acta …, 2017 - Springer
Pathogenic autoantibodies associated with neuromyelitis optica (NMO) induce disease by
targeting aquaporin-4 (AQP4) water channels enriched on astrocytic endfeet at blood–brain …

Neuromyelitis optica and opticospinal multiple sclerosis: mechanisms and pathogenesis

J Kira - Pathophysiology, 2011 - Elsevier
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
while neuromyelitis optica (NMO) is an inflammatory disease of the CNS that selectively …