Computational modeling investigation of pulsed high peak power microwaves and the potential for traumatic brain injury

AM Dagro, JW Wilkerson, TP Thomas, BT Kalinosky… - Science …, 2021 - science.org
When considering safety standards for human exposure to radiofrequency (RF) and
microwave energy, the dominant concerns pertain to a thermal effect. However, in the case …

A 3D computational head model under dynamic head rotation and head extension validated using live human brain data, including the falx and the tentorium

YC Lu, NP Daphalapurkar, AK Knutsen… - Annals of biomedical …, 2019 - Springer
We employ an advanced 3D computational model of the head with high anatomical fidelity,
together with measured tissue properties, to assess the consequences of dynamic loading to …

Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stresses

S Farajzadeh Khosroshahi, X Yin, C K. Donat… - Scientific Reports, 2021 - nature.com
Neurovascular injury is often observed in traumatic brain injury (TBI). However, the
relationship between mechanical forces and vascular injury is still unclear. A key question is …

In vivo measurement of human brain material properties under quasi-static loading

NJ Bennion, S Zappalá, M Potts… - Journal of the …, 2022 - royalsocietypublishing.org
Computational modelling of the brain requires accurate representation of the tissues
concerned. Mechanical testing has numerous challenges, in particular for low strain rates …

Evaluation of the Kinematic Biofidelity and Inter-Test Repeatability of Global Accelerations and Brain Parenchyma Pressure for a Head–Brain Physical Model

Y Li, S Ouellet, AH Vette… - Journal of …, 2021 - asmedigitalcollection.asme.org
Head surrogates are widely used in biomechanical research and headgear assessment.
They are designed to approximate the inertial and mechanical properties of the head and …

White matter tract transcranial ultrasound stimulation, a computational study

C Felix, D Folloni, H Chen, J Sallet… - Computers in Biology and …, 2022 - Elsevier
Low-intensity transcranial ultrasound stimulation (TUS) is poised to become one of the most
promising treatments for neurological disorders. However, while recent animal model …

Integrating material properties from magnetic resonance elastography into subject-specific computational models for the human brain

A Alshareef, AK Knutsen, CL Johnson, A Carass… - Brain multiphysics, 2021 - Elsevier
Advances in brain imaging and computational methods have facilitated the creation of
subject-specific computational brain models that aid researchers in investigating brain …

Development and validation of subject-specific 3D human head models based on a nonlinear visco-hyperelastic constitutive framework

K Upadhyay, A Alshareef… - Journal of the …, 2022 - royalsocietypublishing.org
Computational head models are promising tools for understanding and predicting traumatic
brain injuries. Most available head models are developed using inputs (ie head geometry …

Relating strain fields with microtubule changes in porcine cortical sulci following drop impact

B Hoffe, A Mazurkiewicz, H Thomson, R Banton… - Journal of …, 2021 - Elsevier
The biomechanical response of brain tissue to strain and the immediate neural outcomes
are of fundamental importance in understanding mild traumatic brain injury (mTBI). The …

Influence of surrogate scalp material and thickness on head impact responses: Toward a biofidelic head-brain physical model

Y Li, P Vakiel, K Adanty, S Ouellet, AH Vette… - Journal of the …, 2023 - Elsevier
Advanced physical head models capable of replicating both global kinematics and
intracranial mechanics of the human head are required for head injury research and safety …