The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …

Mechanisms underlying antipsychotic cardiometabolic adverse effects are incompletely
understood. This hampers the identification of high-risk patients, low-risk antipsychotics and …

Rates of obesity are higher than normal across a range of psychiatric disorders, including
major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the …

Abstract Second-generation antipsychotics (SGAs), such as risperidone, clozapine and
olanzapine, are the most common drug treatments for schizophrenia. SGAs presented an …

Importance of the field: Antipsychotic drug is the mainstay of treatment for schizophrenia,
and there are large inter-individual differences in clinical response and side effects …

Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant,
anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric …

While the current antipsychotic medications have profoundly impacted the treatment of
schizophrenia over the past 50 years, the newer atypical antipsychotics have not fulfilled …

Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

After a series of serendipitous discoveries of pharmacological treatments for mania and
depression several decades ago, relatively little progress has been made for novel …

Psychiatric pharmacotherapy with olanzapine is commonplace. We investigated the
influence of CYP1A2* 1F (− 163A, rs762551) and serotonergic polymorphisms on …